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pentobarbital will reduce the level or effect of itraconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can lower panobinostat concentrations by ~70% and result